Dengue viruses,transmitted by the mosquito Aedes aegypti and Aedes albopictus mosquitoes. are widely distributed throughout the tropical and Subtropical areas of the world. There are four known distinct serotypes (dengue virus 1, 2. 3 and 4), In children infection is often subclinical or causes a self-limited febrile disease, However, if the patient is infected second times with a different serotype, a more severe disease.